Eye movement lab

Our focus is to measure and understand the mechanisms involved in eye movements and how the central nervous system is involved in processing visual input and controlling the eye movements. 

Techniques

Electro encephalography - EEG 

Electro encephalography (EEG) derives cortical potentials through electrodes placed on the patients head. We use it to measure intrinsic cortical oscillations and changes in cortical neuronal firing patterns due to visual stimuli presented to the patient. 

Visual evoked potentials - VEP

Visual evoked potentials (VEP) are specific changes in the neuronal firing patterns acquired by an EEG over the occipital region. They represent the response of the visual cortex to visual stimuli. We typically use a checkerboard whose colors flip from black to white and vice versa every other second. VEP is typically used in the clinical context to find characteristic alterations in latencies and amplitudes associated with pathologies of the visual pathway. We use it for basic research of the visual pathway functionality. 

Image 1. Typical configuration of a visual evoked potential using an inverting checkerboard as stimulus.

Eyetracking

We use Eyetracking systems based on camera images of the eye to quantify eye movements. We assess the capabilities of many commercially available Eyetracking systems from budget to high-end solutions, as there are often difficulties in accurate tracking of patients with eye diseases. These systems either are stationary using a camera and a TV or mobile using virtual reality headsets with built in cameras. We perform basic research experiments based on Eyetracking as well as implementing examinations for daily clinical use and comparing these to existing gold standards in eye examination. 

Publications

Prof. Dr. Dr. Mathias Abegg PubMed

Vicini R, Brügger D, Abegg M, Salmen A, Grabe HM. Differences in morphology and visual function of myelin oligodendrocyte glycoprotein  antibody and multiple sclerosis associated optic neuritis. J Neurol. Published online August 12, 2020. doi:10.1007/s00415-020-10097-x

Veselaj K, Kamber N, Briner M, et al. Evaluation of diagnostic criteria and red flags of myelin oligodendrocyte  glycoprotein encephalomyelitis in a clinical routine cohort. CNS Neurosci Ther. Published online October 13, 2020. doi:10.1111/cns.13461 

Van der Stigchel S, Nijboer TCW, Bergsma DP, Abegg M, Barton JJS. Anomalous global effects induced by “blind” distractors in visual hemifield defects. Brain Cogn. 2010;74(1):66-73. doi:10.1016/j.bandc.2010.06.006

Tappeiner C, Barthelmes D, Abegg MH, Wolf S, Fleischhauer JC. Impact of optic media opacities and image compression on quantitative analysis of  optical coherence tomography. Invest Ophthalmol Vis Sci. 2008;49(4):1609-1614. doi:10.1167/iovs.07-1264

Tappeiner C, Sarra G-M, Abegg M. Abuse of vasoconstrictive eyedrops mimicking an ocular pemphigoid. Eur J Ophthalmol. 2009;19(1):129-132. doi:10.1177/112067210901900119

Sylvetsky AC, Nandagopal R, Nguyen TT, et al. Buddy Study: Partners for better health in adolescents with type 2 diabetes. World J Diabetes. 2015;6(18):1355-1362. doi:10.4239/wjd.v6.i18.1355

Simpson SA, Abegg M, Barton JJS. Rapid adaptation of visual search in simulated hemianopia. Cereb Cortex. 2011;21(7):1593-1601. doi:10.1093/cercor/bhq221

Sheldon CA, Abegg M, Sekunova A, Barton JJS. The word-length effect in acquired alexia, and real and virtual hemianopia. Neuropsychologia. 2012;50(5):841-851. doi:10.1016/j.neuropsychologia.2012.01.020

Schwyzer L, Mateos JM, Abegg M, et al. Physiological and morphological plasticity induced by chronic treatment with NT-3 or  NT-4/5 in hippocampal slice cultures. Eur J Neurosci. 2002;16(10):1939-1948. doi:10.1046/j.1460-9568.2002.02259.x

Scheel M, Abegg M, Lanyon LJ, Mattman A, Barton JJ. Eye movement and diffusion tensor imaging analysis of treatment effects in a  Niemann-Pick Type C patient. Mol Genet Metab. 2010;99(3):291-295. doi:10.1016/j.ymgme.2009.10.180

Scheel M, Abegg M, Lanyon LJ, Mattman A, Barton JJ. White and gray matter alterations in adults with Niemann-Pick disease type C: a  cross-sectional study. Neurology. 2011;76(2):201; author reply 201-202. doi:10.1212/WNL.0b013e3181fe7341

Rörig KCO, Colacite J, Abegg MA. [Production of virulence factors in vitro by pathogenic species of the genus  Candida]. Rev Soc Bras Med Trop. 2009;42(2):225-227. doi:10.1590/s0037-86822009000200029

Rastgardani T, Lau V, Barton JJS, Abegg M. Trial history biases the spatial programming of antisaccades. Exp Brain Res. 2012;222(3):175-183. doi:10.1007/s00221-012-3201-x

Ramos CL, de Sousa ESO, Ribeiro J, et al. Microbiological and chemical characteristics of tarubá, an indigenous beverage  produced from solid cassava fermentation. Food Microbiol. 2015;49:182-188. doi:10.1016/j.fm.2015.02.005

Pippi B, Joaquim AR, Lopes W, et al. 8-Hydroxyquinoline-5-sulfonamides are promising antifungal candidates for the  topical treatment of dermatomycosis. J Appl Microbiol. 2020;128(4):1038-1049. doi:10.1111/jam.14545

Pfeffer G, Abegg M, Vertinsky AT, Ceccherini I, Caroli F, Barton JJS. The ocular motor features of adult-onset alexander disease: a case and review of the  literature. J Neuroophthalmol. 2011;31(2):155-159. doi:10.1097/WNO.0b013e31820ecb28

Mühlemann F, Grabe H, Fok A, et al. Homonymous hemiatrophy of ganglion cell layer from retrochiasmal lesions in the  visual pathway. Neurology. 2020;94(3):e323-e329. doi:10.1212/WNL.0000000000008738

Morsdorf F, Kükenbrink D, Schneider FD, Abegg M, Schaepman ME. Close-range laser scanning in forests: towards physically based semantics across  scales. Interface Focus. 2018;8(2):20170046. doi:10.1098/rsfs.2017.0046

Mori M, Abegg MH, Gähwiler BH, Gerber U. A frequency-dependent switch from inhibition to excitation in a hippocampal unitary  circuit. Nature. 2004;431(7007):453-456. doi:10.1038/nature02854

Mitra AR, Abegg M, Viswanathan J, Barton JJS. Line bisection in simulated homonymous hemianopia. Neuropsychologia. 2010;48(6):1742-1749. doi:10.1016/j.neuropsychologia.2010.02.023

Menezes HS, Bueno BBM, Ciulla L, et al. Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced  swimming test. Acta Cir Bras. 2008;23(5):447-450. doi:10.1590/s0102-86502008000500010

Lee H, Abegg M, Rodriguez A, Koehn J, Barton JJS. Why do humans make antisaccade errors? Exp Brain Res. 2010;201(1):65-73. doi:10.1007/s00221-009-2008-x

Kucur ŞS, Márquez-Neila P, Abegg M, Sznitman R. Patient-attentive sequential strategy for perimetry-based visual field acquisition. Med Image Anal. 2019;54:179-192. doi:10.1016/j.media.2019.03.002

Hugel S, Abegg M, de Paola V, Caroni P, Gähwiler BH, McKinney RA. Dendritic spine morphology determines membrane-associated protein exchange between  dendritic shafts and spine heads. Cereb Cortex. 2009;19(3):697-702. doi:10.1093/cercor/bhn118

Häner NU, Dysli M, Abegg M, Zinkernagel MS. Enhanced-depth optical coherence tomography for imaging horizontal rectus muscles in  Graves’ orbitopathy. Graefes Arch Clin Exp Ophthalmol. 2015;253(9):1569-1573. doi:10.1007/s00417-015-3060-9

Hafezi F, Grimm C, Wenzel A, Abegg M, Yaniv M, Remé CE. Retinal photoreceptors are apoptosis-competent in the absence of JunD/AP-1. Cell Death Differ. 1999;6(10):934-936. doi:10.1038/sj.cdd.4400574

Hafezi F, Abegg M, Grimm C, et al. Retinal degeneration in the rd mouse in the absence of c-fos. Invest Ophthalmol Vis Sci. 1998;39(12):2239-2244.

Frantz E, Menezes HS, Lange KC, et al. The effect of maternal hypercholesterolemia on the placenta and fetal arteries in  rabbits. Acta Cir Bras. 2012;27(1):7-12. doi:10.1590/s0102-86502012000100002

Fischer MD, Fleischhauer J, Keusch G, Abegg MH. Rise in intraocular pressure during haemodialysis in a patient with reduced outflow  facility. Br J Ophthalmol. 2007;91(8):1091-1093. doi:10.1136/bjo.2006.110072

Feil M, Moser B, Abegg M. The interaction of pupil response with the vergence system. Graefes Arch Clin Exp Ophthalmol. 2017;255(11):2247-2253. doi:10.1007/s00417-017-3770-2

Feil M, Abegg M, Abegg M. Timing of concurrent visual stimuli determines modulation of saccadic amplitude. J Vis. 2018;18(11):8. doi:10.1167/18.11.8

Egli M, Goldblum D, Kipfer A, et al. Assessment of a new Goldmann applanation tonometer. Br J Ophthalmol. 2012;96(1):42-46. doi:10.1136/bjo.2010.182469

Ebneter A, Jaggi D, Abegg M, Wolf S, Zinkernagel MS. Relationship Between Presumptive Inner Nuclear Layer Thickness and Geographic  Atrophy Progression in Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2016;57(9):OCT299-306. doi:10.1167/iovs.15-18865

Dysli M, Vogel N, Abegg M. Reading performance is not affected by a prism induced increase of horizontal and  vertical vergence demand. Front Hum Neurosci. 2014;8:431. doi:10.3389/fnhum.2014.00431

Dysli M, Keller F, Abegg M. Acute onset incomitant image disparity modifies saccadic and vergence eye movements. J Vis. 2015;15(3). doi:10.1167/15.3.12

Dysli M, Ebneter A, Menke MN, et al. PATIENTS WITH EPIRETINAL MEMBRANES DISPLAY RETROGRADE MACULOPATHY AFTER SURGICAL  PEELING OF THE INTERNAL LIMITING MEMBRANE. Retina. 2019;39(11):2132-2140. doi:10.1097/IAE.0000000000002266

Dysli M, Abegg M. Nystagmus Does Not Limit Reading Ability in Albinism. PLoS One. 2016;11(7):e0158815. doi:10.1371/journal.pone.0158815

Dysli M, Abegg M. Gaze-dependent phoria and vergence adaptation. J Vis. 2016;16(3):2. doi:10.1167/16.3.2

Dysli C, Quellec G, Abegg M, et al. Quantitative analysis of fluorescence lifetime measurements of the macula using the  fluorescence lifetime imaging ophthalmoscope in healthy subjects. Invest Ophthalmol Vis Sci. 2014;55(4):2106-2113. doi:10.1167/iovs.13-13627

da Silva NM, Gentz C de B, Reginatto P, et al. 8-Hydroxyquinoline 1,2,3-triazole derivatives with promising and selective  antifungal activity. Med Mycol. Published online July 21, 2020. doi:10.1093/mmy/myaa061

Cruz AL, Souza FS de, Abegg MA. Anti-Candida and anti-quorum sensing activity of airborne microorganisms detected by  a rapid method. Rev Soc Bras Med Trop. 2019;52:e20180152. doi:10.1590/0037-8682-0152-2018

Ciulla L, Menezes HS, Bueno BBM, Schuh A, Alves RJV, Abegg MP. Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced  swimming test. Acta Cir Bras. 2007;22(5):351-354. doi:10.1590/s0102-86502007000500005

Brazerol J, Iliev ME, Höhn R, Fränkl S, Grabe H, Abegg M. Retrograde Maculopathy in Patients With Glaucoma. J Glaucoma. 2017;26(5):423-429. doi:10.1097/IJG.0000000000000633

Borruat F-X, Dysli M, Voide N, Abegg M. Acetazolamide Reduces Retinal Inner Nuclear Layer Thickness in Microcystic Macular  Edema Secondary to Optic Neuropathy. Eur Neurol. 2018;79(3-4):150-153. doi:10.1159/000487665

Bolognini R, Gerth-Kahlert C, Abegg M, et al. Characterization of two novel intronic OPA1 mutations resulting in aberrant pre-mRNA  splicing. BMC Med Genet. 2017;18(1):22. doi:10.1186/s12881-017-0383-x

Blau JE, Abegg MR, Flegel WA, Zhao X, Harlan DM, Rother KI. Long-term immunosuppression after solitary islet transplantation is associated with  preserved C-peptide secretion for more than a decade. Am J Transplant. 2015;15(11):2995-3001. doi:10.1111/ajt.13383

Benjamin CL, Hosokawa Y, Curtis RM, et al. Environmental Conditions, Preseason Fitness Levels, and Game Workload: Analysis of a  Female NCAA DI National Championship Soccer Season. J Strength Cond Res. 2020;34(4):988-994. doi:10.1519/JSC.0000000000003535

Bär S, Hauf M, Barton JJS, Abegg M. The neural network of saccadic foreknowledge. Exp Brain Res. 2016;234(2):409-418. doi:10.1007/s00221-015-4468-5

Abegg MA, Cella FL, Faganello J, Valente P, Schrank A, Vainstein MH. Cryptococcus neoformans and Cryptococcus gattii isolated from the excreta of  psittaciformes in a southern Brazilian zoological garden. Mycopathologia. 2006;161(2):83-91. doi:10.1007/s11046-005-0186-z

Abegg MA, Alabarse PVG, Schüller AK, Benfato MS. Glutathione levels in and total antioxidant capacity of Candida sp. cells exposed to  oxidative stress caused by hydrogen peroxide. Rev Soc Bras Med Trop. 2012;45(5):620-626. doi:10.1590/s0037-86822012000500015

Abegg MA, Alabarse PVG, Casanova A, et al. Response to oxidative stress in eight pathogenic yeast species of the genus Candida. Mycopathologia. 2010;170(1):11-20. doi:10.1007/s11046-010-9294-5

Abegg MA, Lucietto R, Alabarse PVG, Mendes MFA, Benfato MS. Differential resistance to oxidants and production of hydrolytic enzymes in Candida  albicans. Mycopathologia. 2011;171(1):35-41. doi:10.1007/s11046-010-9346-x

Abegg M, Zinkernagel M, Wolf S. Re: Rönnbäck et al.: Imaging of the macula indicates early completion of structural  deficit in autosomal-dominant optic atrophy (Ophthalmology 2013;120:2672-7). Ophthalmology. 2014;121(6):e29-30. doi:10.1016/j.ophtha.2013.11.044

Abegg M, Zinkernagel M, Wolf S. Microcystic macular degeneration from optic neuropathy. Brain. 2012;135(Pt 12):e225. doi:10.1093/brain/aws215

Abegg M, Tappeiner C, Wolf-Schnurrbusch U, Barthelmes D, Wolf S, Fleischhauer J. Treatment of branch retinal vein occlusion induced macular edema with bevacizumab. BMC Ophthalmol. 2008;8:18. doi:10.1186/1471-2415-8-18

Abegg M, Sharma N, Barton JJS. Antisaccades generate two types of saccadic inhibition. Biol Psychol. 2012;89(1):191-194. doi:10.1016/j.biopsycho.2011.10.007

Abegg M, Rodriguez AR, Lee H, Barton JJS. “Alternate-goal bias” in antisaccades and the influence of expectation. Exp Brain Res. 2010;203(3):553-562. doi:10.1007/s00221-010-2259-6

Abegg M, Manoach DS, Barton JJS. Knowing the future: partial foreknowledge effects on the programming of prosaccades  and antisaccades. Vision Res. 2011;51(1):215-221. doi:10.1016/j.visres.2010.11.006

Abegg MH, Savic N, Ehrengruber MU, McKinney RA, Gähwiler BH. Epileptiform activity in rat hippocampus strengthens excitatory synapses. J Physiol. 2004;554(Pt 2):439-448. doi:10.1113/jphysiol.2003.052662

Abegg MH. Rhythmic synaptic activity induced by mechanical injury of rat CA3 hippocampal area. J Neurotrauma. 2007;24(9):1536-1542. doi:10.1089/neu.2005.360

Abegg M, Gentile E. [Visual training in children]. Ther Umsch. 2016;73(2):73-77. doi:10.1024/0040-5930/a000759

Abegg M, Ebneter A, Dysli M. Reply. Retina. 2019;39(12):e53-e54. doi:10.1097/IAE.0000000000002469

Abegg M, Dysli M, Wolf S, Kowal J, Dufour P, Zinkernagel M. Microcystic macular edema: retrograde maculopathy caused by optic neuropathy. Ophthalmology. 2014;121(1):142-149. doi:10.1016/j.ophtha.2013.08.045

Abegg M, Kurz-Levin M, Helbig H. Retinal detachment in patients with acute retinal necrosis: a case series. Klin Monbl Augenheilkd. 2007;224(4):360-363. doi:10.1055/s-2007-962932

Abegg M, Hafezi F, Wenzel A, Grimm C, Remé CE. [Therapeutic strategies in RP (retinitis pigmentosa): light at the end of the  tunnel?]. Klin Monbl Augenheilkd. 2000;216(2):83-89. doi:10.1055/s-2000-10523

Abegg M, Fleischhauer J, Landau K. Unilateral papilledema after trabeculectomy in a patient with intracranial  hypertension. Klin Monbl Augenheilkd. 2008;225(5):441-442. doi:10.1055/s-2008-1027307